An explosion believed to have been caused by a suicide bomber has hit the popular Istiklal Street in central Istanbul’s Taksim square area.

Government officials said at least five people were killed and 36 were injured – seven seriously – in Saturday morning’s explosion.

The Israeli government confirmed that three of its citizens were among those killed. Iran later said that one of its citizens had also died.

The suspected suicide bomber is also believed to be among those killed. Twelve foreign citizens were among the wounded, including six Israelis, two Irish, one German, one Icelander, one Iranian and one Emirati.

Footage from the scene showed police and emergency services cordoning off the street, which has been completely cleared of people.

Witnesses told Al Jazeera that hundreds of people ran in panic away from the site of the explosion, moments after the incident.

There was no immediate claim of responsibility.

Istiklal street is a long pedestrian thoroughfare that winds its way through the Beyoglu neighbourhood from Taksim Square.

It is rimmed by hundreds of shops and would have been filled with pedestrians at the time of the explosion.

Al Jazeera’s Jamal Elshayyal said the location of the explosion was the equivalent of a bomb going off in Oxford Street in London or Fifth Avenue in New York.

The explosion comes as Turkey is on edge following two recent suicide bomb attacks in the capital, Ankara, which were claimed by a Kurdish group, that is an off-shoot of the outlawed Kurdistan Workers’ Party, or PKK.

Turkey has been fighting on multiple fronts. As part of a US-led coalition, it is battling the Islamic State of Iraq and the Levant (ISIL, also known as ISIS), which has seized territory in neighbouring Syria and Iraq.

Witnesses told Al Jazeera that hundreds of people ran in panic away from the site of the explosion [Reuters] It is also battling the PKK in its southeast, where a two-and-a-half-year ceasefire collapsed last July, prompting the worst violence since the 1990s.

Turkey sees the unrest in its largely Kurdish southeast as deeply linked to events in northern Syria, where the Kurdish YPG militia has seized territory as it fights both ISIL and rebels battling President Bashar al-Assad.

ISIL has carried out at least four bomb attacks on Turkey since June 2015, including a suicide bombing which killed 10 German tourists in central Istanbul in January.

[Source: Al-Jazeera]